A score test for the linkage analysis of qualitative and by Dudoit S., Speed T. P. PDF

By Dudoit S., Speed T. P.

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Extra info for A score test for the linkage analysis of qualitative and quantitative traits based on identity [...]

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The Mendelian law stating that when two or more contrasted pairs of characters are involved in a cross the pairs are separated independent of one another in the germ cells means, Morgan asserted, that ‘‘the germ plasm must, therefore, be made up of independent elements of some kind. ’’40 16 C LASSICAL M ENDELIAN G ENETICS Morgan made no mention of the fact that up to this point he had always called these elements factors. ’’ Although he gave no reason for changing his language, it is hardly likely that Morgan did not notice this abrupt shift or had no underlying reason for it.

20 It is not unlikely that conversations with Muller on this topic significantly influenced Delbrück’s thinking at this formative time in his transition. Delbrück arrived at Caltech in October 1937. During his first weeks there he read some reprints given to him by Sturtevant, who suggested that he might occupy himself with some unresolved linkage problems on the fourth chromosome of Drosophila. As he recalled much later, Delbrück quickly became disconsolate. 21 Although there is undoubtedly a core of truth in this memory, it has led to some misunderstandings.

There is as yet no empiric evidence, and only doubtful theoretical ground, for assuming that the lines of demarcation between genes, as defined on any one of these systems, would coincide with those on any of the others, or even for assuming, in the case of any one of these systems, . . 73 Although he rejected the more radical aspects of Goldschmidt’s position, 26 C LASSICAL M ENDELIAN G ENETICS Muller agreed with him that ‘‘the ‘gene,’ in the rather loose sense in which it has so long been taken for granted by most geneticists, may perhaps be genetically further divisible, even into many genetically linearly arranged portions of semi-autonomous character .

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A score test for the linkage analysis of qualitative and quantitative traits based on identity [...] by Dudoit S., Speed T. P.


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